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Research Goal:
to understand the role that two alternatively spliced forms of
the Disabled-1 (Dab1) gene (Dab1-early and Dab1-late) play in the
developing chick retina.
Techniques: In ovo electroporation of chick
embryos; yeast two-hybrid analysis to identify proteins
interacting with Dab1-early and Dab1-late; biochemical assays to
study the role of Dab1 in signal transduction.
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Publications:
Gao, Z., Yang, J., Huang, Y. and Yu, Y. N-methyl-N’-nitro-N-nitrosoguanidine
interferes with the epidermal growth factor receptor-mediated
signaling pathway. Mutation Res. 570: 175-184 (2005)
Gao, Z., Jin, J., Yang, J. and Yu, Y. Zinc finger proteins and other
transcription regulators as response proteins in benzo[alpha}pyrene
exposed cells. Mutation Res. 550: 11-24 (2004).
Jin, J., Yang, J., Gao, Z. and Yu, Y. Altered expression of zinc
finger proteins, ADAMs, and integrin-related proteins following
treatment of cultured human cells with a low concentration of
N-methyl-N’-nitro-N-nitrosoguanidine in human in human amnion FL
cells Environ. Mol. Mutagene. 43: 93099 (2004)
Jin, J., Gao, Z., Guo, L., Yang, J. and Yu, Y. Altered expression of
zinc finger protein, ADAMs, and integrin-related proteins following
treatment of cultured human cells with a low concentration of
N-methyl-N’-nitro-N-nitrosoguanidine. Environ. Mol. Mutagen. 41:
344-352 (2003).
Katyal, S., Gao, Z., Liu, R.-Z. and Godbout,
R. Evolutionary conservation of alternative splicing in chicken.
Cytogen. Genome Res.117:146-157 (2007).
Katyal, S*., Gao, Z*., Monckton, E.A., Glubrecht, D.D. and Godbout,
R. The hierarchical nature of Dab1 tyrosine phosphorylation specifies
Src-family kinase activation and neuritogenesis. J. Mol. Biol. 368:
349-364 (2007).
*Co-first authors
Liu, R.-Z., Mita, R., Beaulieu, M., Gao, Z. and Godbout, R. Fatty acid binding proteins in brain development and diseases. Int. J. Dev. Biol. 54: 1229-1239 (2010).
Gao, Z., Monckton, E.A., Glubrecht, D.D. and Godbout, R. Early Isoform of Disabled-1 Functions Independently of Reelin-mediated Tyrosine Phosphorylation in Chick Retina. Mol. Cell. Biol. 30: 4339-4353 (2010).
Gao, Z. and Godbout, R. Serine Phosphorylation Regulates Disabled-1 Early Isoform Turnover Independently of Reelin. Cell. Signalling.(in press).
Presentations:
Gao, Z., Katyal, S., Monckton, E and Godbout, R. Functional
characterization of Dab1 alternative splicing in chick retina.
Alberta Cancer Board Annual Research Meeting, Banff, Alberta (2004).
Gao, Z., Katyal, S., Monckton, E.A. and Godbout, R. Functional
characterization of the alternative splicing of Disabled-1 in the
chick retina. 3rd Canadian Developmental Biology Conference, Mont-Tremblant,
Quebec (April 6-9, 2006).
Gao, Z. Katyal, S., Monckton, E.A. and Godbout, R. Analysis of
alternatively spliced Disabled-1 isoforms in developing retina.
Gordon Research Conference – Molecular and Cellular Neurobiology,
Hong-Kong (June 11-16, 2006).
Gao, Z. Katyal, S., Monckton, E.A. and Godbout, R. Characterization
of alternatively spliced Disabled-1 isoforms in developing retina.
ACB Annual Research Meeting, Banff (November 7-9, 2006).
Gao, Z., Katyal, S., Monckton, E. and Godbout, R. Functional analysis
of alternatively spliced Disabled-1 isoforms in the developing
retina. ”Phosphorylation, Signaling & Diseases”, Cold Spring Harbour
Laboratory (2007).
Gao, Z., Katyal, S., Monckton, E. and Godbout, R. Functional analysis of alternatively spliced Disabled-1 isoforms in the developing retina. 2007 Alberta Vision Science Symposium, Edmonton, Alberta, August 31 – September 1, 2007.
Gao, Z., Katyal, S., Monckton, E.A. and Godbout, R. Characterization of alternative spliced Disabled-1 isoforms in developing retina. Alberta Cancer Research Institute Research Meeting, Banff, Alberta (November 6-8, 2007).
Gao, Z., Katyal, S., Monckton, E. and Godbout, R. Role of alternatively spliced Disabled-1 in developing retina. 4th Canadian Developmental Biology Conference, Banff, Alberta (February 28 – March 2, 2008).
Gao, Z., Katyal, S.K., Monckton, E.A. and Godbout, R. Role of alternatively spliced disabled-1 in developing retina. 17th Biennial Meeting of the International Society for Developmental Neuroscience, Asilomar, California (June 1-4, 2008). Published in Int. J. Dev. Neurosci. 26(8): 876 (P2.29) (2008).
Gao, Z., Katyal, S., Monckton, E.A. and Godbout, R. Role of alternatively spliced Disabled-1 in developing retina. Alberta Cancer Research Institute Research Meeting, Banff, Alberta (November 25-27, 2008).
Gao, Z., Monckton, E.A., Katyal, S. and Godbout, R. Role of alternatively spliced Disabled-1 isoforms in developing retina. 3rd Annual Canadian Neuroscience Meeting, Vancouver BC (May 24-27, 2009).
Gao, Z., Monckton, E.A., Glubrecht, D.D. and Godbout, R. A Reelin-independent role for the Disabled-1 early isoform in retinal progenitor cells. XIX Biennial Meeting of the International Society for Eye Research, Montreal Quebec (July 18-21, 2010).
Gao, Z., Monckton, E.A., Glubrecht, D.D. and Godbout, R. A novel role for the Disabled-1 early isoform in retinal progenitor cells. Ophthalmology Research Day 2010, University of Alberta (May 28, 2010).
Gao, Z., Monckton, E.A. and Godbout, R. A Reelin-independent Role for the Disabled-1 Early Isoform in Retinal Progenitor Cells. XIX Biennial Meeting of the International Society for Eye Research (ISER 2010), Montreal, Quebec (July 18-23, 2010) (selected for oral presentation).
Awards:
Department of Oncology endowed studentship (stipend, tuition
and travel award)
Alberta Cancer Board Studentship
Alberta Heritage Foundation for Medical Research
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