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Research Goal:
to understand the role that two alternatively spliced forms of
the Disabled-1 (Dab1) gene (Dab1-early and Dab1-late) play in the
developing chick retina.
Techniques: In ovo electroporation of chick
embryos; yeast two-hybrid analysis to identify proteins
interacting with Dab1-early and Dab1-late; biochemical assays to
study the role of Dab1 in signal transduction.
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Publications:
Gao, Z., Yang, J., Huang, Y. and Yu, Y. N-methyl-N’-nitro-N-nitrosoguanidine
interferes with the epidermal growth factor receptor-mediated
signaling pathway. Mutation Res. 570: 175-184 (2005)
Gao, Z., Jin, J., Yang, J. and Yu, Y. Zinc finger proteins and other
transcription regulators as response proteins in benzo[alpha}pyrene
exposed cells. Mutation Res. 550: 11-24 (2004).
Jin, J., Yang, J., Gao, Z. and Yu, Y. Altered expression of zinc
finger proteins, ADAMs, and integrin-related proteins following
treatment of cultured human cells with a low concentration of
N-methyl-N’-nitro-N-nitrosoguanidine in human in human amnion FL
cells Environ. Mol. Mutagene. 43: 93099 (2004)
Jin, J., Gao, Z., Guo, L., Yang, J. and Yu, Y. Altered expression of
zinc finger protein, ADAMs, and integrin-related proteins following
treatment of cultured human cells with a low concentration of
N-methyl-N’-nitro-N-nitrosoguanidine. Environ. Mol. Mutagen. 41:
344-352 (2003). Katyal, S., Gao, Z., Liu, R.-Z. and Godbout,
R. Evolutionary conservation of alternative splicing in chicken.
Cytogen. Genome Res. (in press).
Katyal, S*., Gao, Z*., Monckton, E.A., Glubrecht, D.D. and Godbout,
R. The hierarchical nature of Dab1 tyrosine phosphorylation specifies
Src-family kinase activation and neuritogenesis. J. Mol. Biol. 368:
349-364 (2007).
*Co-first authors
Presentations:
Gao, Z., Katyal, S., Monckton, E and Godbout, R. Functional
characterization of Dab1 alternative splicing in chick retina.
Alberta Cancer Board Annual Research Meeting, Banff, Alberta (2004).
Gao, Z., Katyal, S., Monckton, E.A. and Godbout, R. Functional
characterization of the alternative splicing of Disabled-1 in the
chick retina. 3rd Canadian Developmental Biology Conference, Mont-Tremblant,
Quebec (April 6-9, 2006).
Gao, Z. Katyal, S., Monckton, E.A. and Godbout, R. Analysis of
alternatively spliced Disabled-1 isoforms in developing retina.
Gordon Research Conference – Molecular and Cellular Neurobiology,
Hong-Kong (June 11-16, 2006).
Gao, Z. Katyal, S., Monckton, E.A. and Godbout, R. Characterization
of alternatively spliced Disabled-1 isoforms in developing retina.
ACB Annual Research Meeting, Banff (November 7-9, 2006).
Gao, Z., Katyal, S., Monckton, E. and Godbout, R. Functional analysis
of alternatively spliced Disabled-1 isoforms in the developing
retina. ”Phosphorylation, Signaling & Diseases”, Cold Spring Harbour
Laboratory (2007).
Awards:
Department of Oncology endowed studentship (stipend, tuition
and travel award)
Alberta Cancer Board Studentship
Alberta Heritage Foundation for Medical Research
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