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Research Project:
Brain fatty acid binding protein (B-FABP) is a member of a family
of proteins implicated in cancer formation and cellular
differentiation. B-FABP is believed to bind to fatty acid ligands
such as docosahexanoic acid (DHA) and deliver these ligands to
nuclear receptors implicated in transcriptional regulation.
Previous work from the lab has shown that B-FABP is expressed in
malignant glioma tumours and cell lines. As malignant glioma
tumours are highly aggressive and invasive, we need to find new
approaches for the treatment of these cancers. I am studying how
B-FABP expression affects the growth properties of malignant
glioma cells. I am particularly interested in determining whether
B-FABP expression leads to increased invasiveness and cell
motility.
Techniques: confocal microscopy, tissue
culture, motility assays, protein extraction, western blot
analysis, yeast two-hybrid analysis
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Presentations:
Mita, R., Roy, K., Rowe, J., Coles, J., Dabbagh, L., Hao, C and
Godbout, R. Subcellular localization of brain fatty acid-binding
protein in malignant glioma. Alberta Cancer Board Annual Research
Meeting, Banff, Alberta (2004).
Mita, R. and Godbout, R. Subcellular localization of brain fatty
acid-binding protein in malignant glioma. ACB Research Meeting,
Banff, Alberta (2005).
Mita, R., Coles, J.E., Sung, R. and Godbout, R. Subcellular
localization of brain fatty acid-binding protein in malignant glioma.
ACB Research Meeting, Banff, Alberta (2006)
Mita, R., Coles, J.E., Glubrecht, D. and Godbout, R. Expression of B-FABP
enhances migration of malignant glioma cells. The 6th Conference on
Lipid Binding Proteins, Vancouver, BC (2007)
Publications:
Mita, R. Coles, J.E., Glubrecht, D., Sung, R. Sun, X. and Godbout, R.
B-FABP-expressing radial glial cells – the malignant glioma
cell-of-origin? Neoplasia 9: 734-377 (2007).Awards
CIHR Translational Research Training in Cancer fellowship
Poster award
- The 6th Conference on Lipid Binding Proteins, Vancouver, BC (2007)
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