Ismail Ismail
Principal Investigator
DNA Damage ResponseResearch Overview
Investigates fundamental mechanisms of DNA damage repair with focus on B-cell malignancies, particularly multiple myeloma. Research bridges basic DNA damage response biology with translational oncology.
The Ismail laboratory has made significant contributions to understanding DNA damage response mechanisms in B-cell malignancies. The research has particular relevance for multiple myeloma, a currently incurable plasma cell cancer that remains highly dependent on DNA repair for survival. Key discoveries include identifying specific vulnerabilities in DNA repair pathways that can be exploited therapeutically, leading to new combination treatment strategies.
Research Focus
DNA Double-Strand Break Repair
Investigation of homologous recombination and non-homologous end joining pathways, with particular emphasis on how B-cell malignancies exploit or become dependent on specific repair mechanisms.
Replication Stress Response
Study of how cells cope with obstacles to DNA replication, including the role of replication protein A (RPA) and ATR signaling in maintaining fork stability during oncogene-induced replication stress.
Multiple Myeloma Biology
Comprehensive analysis of DNA repair pathway dependencies in multiple myeloma, identifying vulnerabilities that can be targeted with novel therapeutic approaches and combination strategies.
Translational Applications
Development of predictive biomarkers and therapeutic strategies based on DNA repair deficiencies, with focus on personalized medicine approaches for B-cell malignancies.
Contact & Lab Information
Location
Cross Cancer Institute, University of Alberta
Department
Department of Oncology