Selected Publications

Godbout, R. and Squire, J. Amplification of a DEAD box protein gene in retinoblastoma cell lines. Proc. Natl. Acad. Sci. U.S.A. 90:7578-7582 (1993). PDF

Squire, J.A., Thorner, P.S., Weitzman, S., Maggi, J.D., Dirks, P., Doyle, J. and Godbout, R. Co-amplification of MYCN and a novel DEAD box gene (DDX1) in primary neuroblastoma. Oncogene 10:1417-1422 (1995).PDF

Bisgrove, D.A., Monckton, E.A. and Godbout, R. Involvement of AP-2 in regulation of the R-FABP gene in the developing chick retina. Mol. Cell. Biol.17: 5935-5945 (1997). PDF

Godbout, R., Bisgrove, D.A., Shkolny, D. and Day, R.S. III. Correlation of B-FABP and GFAP expression in malignant glioma. Oncogene 16: 1955-1962 (1998). PDF

Godbout, R., Packer, M. and Bie, W. Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines. J. Biol. Chem. 273:21161-21168 (1998). PDF

Bisgrove, D.A., and Godbout, R. Differential Expression of Transcription Factors AP-2α and AP-2ß in the Developing Chick Retina: Repression of the R-FABP gene. Dev. Dyn. 214:195-206 (1999). PDF

Bisgrove, D.A., Monckton, E.A., Packer, M. and Godbout, R. Regulation of brain fatty-acid binding protein expression by differential phosphorylation of Nuclear Factor 1 in malignant glioma cell lines. J. Biol. Chem. 275:30668-30676 (2000).PDF

Godbout, R. and Monckton, E.A. Differential regulation of the aldehyde dehydrogenase 1 gene in embryonic chick retina and liver. J. Biol. Chem. 276:32896-32904 (2001). PDF

Bléoo, S., Sun, X., Hendzel, M.J., Rowe, J.M., Packer, M. and Godbout, R. Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-mRNA. Mol. Biol. Cell 12:3046-3059 (2001). PDF

Godbout, R., Andison, R., Katyal, S. and Bisgrove, D.A. Isolation of a novel cDNA enriched in the undifferentiated chick retina and lens. Dev. Dyn. 227: 409-415 (2003). PDF

Katyal, S. and Godbout, R. Dab1 alternative splicing modulates the disabled (Dab1) pathway in the developing chick retina. EMBO J. 23: 1878-1888 (2004). PDF

Li, L., Roy, K., Katyal, S., Sun, X., Bléoo, S. and Godbout, R. Dynamic Nature of Cleavage Bodies and their spatial relationship to DDX1 bodies, Cajal bodies and gems. Mol. Biol. Cell 17: 1126-1140 (2006). PDF

Katyal, S., Gao, Z., Monckton, E., Glubrecht, D and Godbout, R. Hierarchical Disabled-1 Tyrosine Phosphorylation in Src Family Kinase Activation and Neurite Formation. J. Mol. Biol. 368: 349-364 (2007). PDF

Mita, R., Coles, J.E., Glubrecht, D.R., Sung, R., Sun, X. and Godbout,  R. B-FABP–Expressing Radial Glial Cells: The Malignant Glioma. Neoplasia 9: 734 – 744 (2007). PDF

Godbout, R., Li, L., Liu, R. and Roy, K. Role of DEAD box1 in Retinoblastoma and Neuroblastoma. Future Oncology 3(5): 575-587 (2007). PDF

Li, L., Monckton, E.A. and Godbout, R. A Role for DEAD Box 1 at DNA Double-Strand Breaks. Mol. Cell. Biol. 28: 6413-6425 (2008).  PDF

Li, X., Glubrecht, D., Mita, R. and Godbout R.  Expression of AP-2 in the Developing Chick Retina. Developmental Dynamics 237:3210–3221(2008).  PDF

Liu, R.-Z., Li, X. and Godbout R. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. Genomics 92: 436-445 (2008).  PDF

Brun, M.1, Coles, J.E.1, Monckton, E.A., Glubrecht, D.D., Bisgrove, D.A. and Godbout, R. Nuclear Factor I Regulates Brain Fatty Acid-binding Protein and Glial Fibrillary Acidic Protein Gene Expression in Malignant Glioma Cell Lines.  J. Mol. Biol. 391: 282-300 (2009). 1co-first authors. PDF

Glubrecht, D.D., Kim, J.-H., Russell, L. Bamforth, J.S. and Godbout, R. Differential CRX and OTX2 Expression in Human Retina and Retinoblastoma. J. Neurochem. 111: 250-263 (2009).

Liu, R.-Z., Mita, R., Beaulieu, M., Gao, Z. and Godbout, R. Fatty acid binding proteins in brain development and diseases. Int. J. Dev. Biol. 54: 1229-1239 (2010). PDF

Li. X., Glubrecht, D.D. and Godbout, R. The AP-2 transcription factor induces apoptosis in retinoblastoma cells. Genes Chromosomes Cancer 49: 819-830 (2010). PDF

Gao, Z., Monckton, E.A., Glubrecht, D.D. and Godbout, R. Early Isoform of Disabled-1 Functions Independently of Reelin-mediated Tyrosine Phosphorylation in Chick Retina. Mol. Cell. Biol. 30: 4339-4353 (2010). PDF

Mita, R., Beaulieu, M.J., Field, C. and Godbout, R. Brain Fatty Acid-binding Protein and ω-3/ω-6 Fatty Acids: Mechanistic Insight into Malignant Glioma Cell Migration. J. Biol. Chem. 285: 37005-37015 (2010). PDF

Germain, D.R., Graham, K., Glubrecht, D.D., Hugh, J.C., Mackey, J.R. and Godbout, R. DEAD Box 1: A Novel and Independent Prognostic Marker for Early Recurrence in Breast Cancer. Breast Cancer Res. Treat. 127: 53-63 (2011). PDF

Liu, R.-Z., Graham, K., Glubrecht, D.D., Germain, D.R., Mackey, J.R. and Godbout, R. Association of FABP5 expression with poor survival in triple-negative breast cancer: implication for retinoic acid therapy. Am. J. Pathol. 178: 997-1008 (2011). PDF

Gao, Z. and Godbout, R. Serine Phosphorylation Regulates Disabled-1 Early Isoform Turnover Independently of Reelin. Cell. Signal. 23: 555-565 (2011). PDF

Katyal, S., Glubrecht, D.D., Li, L. Gao, Z. and Godbout, R. Disabled-1 alternative splicing in human fetal retina and neural tumors. PLoS ONE 6: e28579 (pgs. 1- 12) (2011). PDF

Liu, R.-Z., Graham, K., Glubrecht, D.D., Lai, R., Mackey, J.R. and Godbout, R. A Fatty Acid-binding Protein 7/RXRb Pathway Enhances Survival and Proliferation in Triple-negative Breast Cancer. J. Pathol. 228: 310-321 (2012).

Liu, R.Z., Monckton, E.A. and Godbout, R. Regulation of the FABP7 gene by PAX6 in malignant glioma cells. Biochem. Biophys. Res. Comm. 422: 482–487 (2012).

Gao, Z., Poon, H.Y., Li, L., Li, X., Palmesino, E., Glubrecht, D., Colwill, K., Dutta, I., Kania, A., Pawson, T. and Godbout, R. Splice-mediated motif switching regulates Disabled-1 phosphorylation and SH2 domain interactions. Mol. Cell. Biol. 32: 2794-2808 (2012). PDF

Gao, Z. and Godbout, R. Reelin-Disabled-1 signaling in neuronal migration: Splicing takes the stage. Cell. Mol. Life Sci. 70: 2319 – 2329 (2013). PDF

Rushlow, D.E., Mo, B.M., Kennett, J.Y., Yee, S., Pajovic, S., Theriault, B.L., Prigoda-Lee, N.L., Spencer, C., Dimaras, H., Corson, T.W., Pang, R., Massey, C., Godbout, R., Jiang, Z., Zacksenhaus, E., Paton, K., Moll, A.C., Houdayer,C., Raizis, A., Halliday, W., Lam, W.L., Boutros, P.C., Lohmann, D., Dorsman, J. and Gallie, B. Characterization of retinoblastoma tumours without RB1 mutations: genomic, gene expression and clinical studies. Lancet Oncol. 14: 327-334 (2013).

Brun, M., Glubrecht, D.D., Baksh, S. and Godbout, R. Calcineurin regulates Nuclear Factor I dephosphorylation and activity in malignant glioma cell lines. J. Biol. Chem. 288: 24104 – 24115 (2013). PDF

Elsherbiny, M., Emara, M. and Godbout, R. Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. Prog. Lipid Res. 52: 562-570 (2013). PDF

Chou, C.-F., Lin, W.-J., Lin, C.-C., Luber, C.A., Godbout, R., Mann, M. and Chen, C.Y. DEAD Box Protein DDX1 Regulates Cytoplasmic Localization of KSRP. PLoS ONE 8: e73752 (pgs. 1-8) (2013).

Li, X., Monckton, E.A. and Godbout, R. Ectopic Expression of Transcription Factor AP-2delta in Developing Retina: Effect on PSA-NCAM and Axon Routing. J. Neurochem. 129: 72–84 (2014).

Li, X., Persad, A.R.L., Monckton, E.A. and Godbout, R. Transcription Factor AP-2delta Regulates the Expression of Polysialyltransferase ST8SIA2 in Chick Retina. FEBS Lett. 588: 770–775 (2014). PDF

Katchinskiy, N., Godbout, R., Goez, H.R. and Elezzabi, A.Y. Femtosecond Laser-Induced Cell-Cell Surgical Attachment. Lasers Surg. Med. 46: 335-341 (2014).

Hildebrandt, M.R., Germain, D.R., Monckton, E.A., Brun, M. and Godbout, R. Ddx1 knockout results in transgenerational wild type lethality in mice. Sci. Rep. 5: 9829, pgs. 1-8 (2015). PDF

Liu, R.-Z., Garcia, E., Glubrecht, D.D., Poon, H.Y., Mackey, J.R. and Godbout, R. CRABP1 is Associated with a Poor Prognosis in Breast Cancer: Adding to the Complexity of Breast Cancer Cell Response to Retinoic Acid. Mol. Cancer 14:129, pgs. 1-16 (2015). PDF

Germain, D., Li, L., Hildebrandt, M.R., Simmonds, A.J., Hughes, S.C. and Godbout, R. Loss of Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis. Dev. Biol. 407: 232-245 (2015). PDF

Elsherbiny, M.E., Goruk, S., Monckton, E.A., Richard, C., Brun, M., Emara, M., Field, C.J. and Godbout, R. Long-term effect of docosahexaenoic acid feeding on lipid composition and brain fatty acid-binding protein expression in rats. Nutrients 7: 8802-8817 (2015). PDF

Liu, R.-Z., Li, S., Garcia, E., Glubrecht, D.D, Poon, H.-Y., Easaw, J.C. and Godbout, R. Association between cytoplasmic CRABP2, altered retinoic acid signaling and poor prognosis in glioblastoma. GLIA 64: 963-976 (2016). PDF

Li, X., Gaillard, F., Monckton, E.A., Glubrecht, D.D., Persad, A. R. L., Moser, M., Sauve, Y and Godbout, R. Loss of AP-2delta Reduces Retinal Ganglion Cell Numbers and Axonal Projections to the Superior Colliculus. Mol. Brain 9: 62 (pgs. 1-21) (2016). PDF

Li, L., Germain, D.R., Poon, H.-Y., Hildebrandt, M.R., Monckton, E.A., McDonald, D., Hendzel, M. and Godbout, R. DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double Strand Breaks. Mol. Cell. Biol. 36: 2794-2810 (2016). PDF

Li, L., Poon, H.-Y., Hildebrandt, M.R., Monckton, E.A., Germain, D.R., Fahlman, R.P. and Godbout, R. Role for RIF1-Interacting Partner DDX1 in BLM Recruitment to DNA Double-Strand Breaks. DNA Repair 55: 47-63 (2017). PDF

Jain, S., Glubrecht, D.D., Germain, D.R., Moser, M. and Godbout, R. AP-2e Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells. Sci. Rep. 8:3386 (pgs. 1-13) (2018). doi: 10.1038/s41598-018-21822-y. PDF

Elsherbiny, M.E., Chen, H., Emara, M. and Godbout, R. w-3 and w-6 Fatty Acids Modulate Conventional and Atypical Protein Kinase C in a Brain Fatty Acid Binding Protein Dependent Manner in Glioblastoma Multiforme. Nutrients 10: 454 (pgs. 1-11) (2018). PDF

Brun, M., Jain, S., Monckton, E.A. and Godbout, R. Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma. Neoplasia 20: 1023-1037 (2018). (Brun and Jain – co-first authors.  PDF

Liu, R.-Z., Vo, T.M., Jain, S., Choi, W.-S., Garcia, E., Monckton, E.A., Mackey, J.R. and Godbout, R. NFIB promotes cell survival by directly suppressing p21 transcription in p53-mutated triple-negative breast cancer. J. Pathol. 247: 186-198 (2019). PDF

Vo, T.M., Burchett, R., Brun, M., Monckton, E.A., Poon, H.-Y. and Godbout, R. Effects of nuclear factor I phosphorylation on calpastatin (CAST) gene variant expression and subcellular distribution in malignant glioma cells. J. Biol. Chem. 294: 1173-1188 (2019). PDF

Vo, T.M., Jain, S. Burchett, R., Monckton, E.A. and Godbout, R. A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration. J. Biol. Chem. 294: 12638-12654 (2019). PDF

Hildebrandt, M.R.*, Wang, Y.*, Li, L., Yasmin, L., Glubrecht, D.D. and Godbout, R. Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout. Dev. Biol. 455: 420-433 (2019). *co-first authors. PDF

Liu, R.-Z., Choi, W.-S., Jain, S., Dinakaran, D., Xu, X., Han, W.H., Yang, X.-H., Glubrecht, D., Moore, R.B., Lemieux, H. and Godbout, R. The FABP12/PPARgamma pathway promotes metastatic transformation by inducing epithelial-to-mesenchymal transition and lipid-derived energy production in prostate cancer cells. Mol. Oncol. 14: 3100-3120 (2020). PDF

Liu, R.-Z. and Godbout, R. An amplified fatty acid-binding protein gene cluster in prostate cancer: emerging roles in lipid metabolism and metastasis. Cancers 12(12): 3823 (2020). PDF

Xu, X.*, Wang, Y.*, Choi, W.-S., Sun, X. and Godbout, R. Super resolution microscopy reveals DHA-dependent alterations in glioblastoma membrane remodelling and cell migration. Nanoscale 13, 9706–9722 (2021). * co-first authors. PDF

Choi, W.-S.*, Xu, X.*, Xia Xu, Goruk, S., Wang, Y., Patel, S., Chow, M., Field, C.J. and Godbout, R. FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-Like Cells. Nutrients 13: 2664 (2021). * co-first authors . PDF