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Research Goal:
to uncover the function of brain fatty acid-binding protein (B-FABP)
in human malignant glioma cells.
Techniques: RT-PCR; northern
hybridization; western blotting and hybridization;
immunofluorescent labeling and confocal imaging;
immunohistochemical analysis; immunoprecipitation; cDNA cloning;
trans-activity assay of PPARs; apoptosis assay
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Publications:
Liu RZ, Sharma KM, Sun Q. Degrave A, Thisse C, Thisse B, Denovan-Wright
EM,Wright JM (2005). Retention of the duplicated cellular retinoic
acid-binding protein 1 genes (crabp1a and crabp1b) in the zebrafish
genome by subfunctionaliza-tion of tissue-specific expression. FEBS
J. 272: 3561-3571.
Liu RZ, Sun Q. Degrave A, Thisse C, Thisse B, Denovan-Wright
EM,Wright JM. (2005). The zebrafish cellular retinol-binding protein
genes are duplicated and differentially transcribed in the developing
and adult tissues. Mol Biol Evol. 22(3):469-477.
Sharma MK, Saxena V, Liu RZ Thisse C, Thisse B, Denovan-Wright EM,
Wright JM (2005). Differential expression of the duplicated cellular
retinoic acid-binding protein 2 genes (crabp2a and crabp2b) during
zebrafish embryonic development. Gene Expr Patterns (Mechanism of
Development). 5(3):371-379.
Liu RZ, Denovan-Wright EM, Degrave A, Thisse C, Thisse B, Wright JM
(2004) Differential expression of duplicated genes for brain-type
fatty acid-binding proteins (fabp7a and fabp7b) during early
development of the CNS in zebrafish (Danio rerio). Gene Expr Patterns
(Mechanism of Development). 4(4):379-387.
Liu, RZ Denovan-Wright EM, Degrave A, Thisse C, Thisse B, Wright JM
(2004) Spatio-temporal distribution of cellular retinol-binding
protein gene transcripts (CRBPI and CRBPII) in the developing and
adult zebrafish (Danio rerio). Eur J Biochem. 271(2):339-348.
Liu RZ, Denovan-Wright EM, Wright JM (2003) Structure, mRNA
expression and linkage mapping of the brain-type fatty acid-binding
protein gene (fabp7) from zebrafish (Danio rerio). Eur J Biochem.
270(4):715-725.
Liu RZ, Denovan-Wright EM, Wright JM (2003) Structure, linkage
mapping and expression of the heart-type fatty acid-binding protein
gene (fabp3) from zebrafish (Danio rerio). Eur J Biochem.
270(15):3223-3234.
Presentations:
Liu, RZ. and Godbout, R. Up-regulation of fatty acid-binding proteins
in human malignant glioma cells. ASCB 44th Annual Meeting,
Washington, DC. USA (2004).
Liu, RZ. Hao, C. and Godbout, R. Expression and induction of fatty
acid binding proteins in human malignant glioma cells. ACB Annual
Research Meeting, Banff, Canada (2004).
Liu, RZ. Denovan-Wright, EM. and Wright, JM. A novel member of the
fatty acid binding protein multigene family: cDNA sequence,
tissue-specific distribution and down-regulation of its mRNA during
oogenesis in zebrafish (Danio rerio). The 5th International
conference on zebrafish development & Genetics, Madison, USA (2002)
Funding source:
Alberta Cancer Foundation Fellowship |
