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Epigenetics (2000-2006)

McManus, K.J., V.L. Biron, R. Heit, D.A. Underhill, and M.J. Hendzel. 2006. Dynamic Changes in Histone H3 Lysine 9 Methylations: IDENTIFICATION OF A MITOSIS-SPECIFIC FUNCTION FOR DYNAMIC METHYLATION IN CHROMOSOME CONGRESSION AND SEGREGATION. J Biol Chem. 281:8888-97.

McManus, K.J., and M.J. Hendzel. 2005a. ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells. Mol Biol Cell. 16:5013-25.

McManus, K.J., and M.J. Hendzel. 2005b. Using quantitative imaging microscopy to define the target substrate specificities of histone post-translational-modifying enzymes. Methods. 36:351-61.

Keats, J.J., C.A. Maxwell, B.J. Taylor, M.J. Hendzel, M. Chesi, P.L. Bergsagel, L.M. Larratt, M.J. Mant, T. Reiman, A.R. Belch, and L.M. Pilarski. 2005. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. Blood. 105:4060-9.

Biron, V.L., K.J. McManus, N. Hu, M.J. Hendzel, and D.A. Underhill. 2004. Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development. Dev Biol. 276:337-51.

McManus, K.J., and M.J. Hendzel. 2003. Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin. Mol Cell Biol. 23:7611-27.

Fischle, W., F. Dequiedt, M.J. Hendzel, M.G. Guenther, M.A. Lazar, W. Voelter, and E. Verdin. 2002. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell. 9:45-57.

Boisvert, F.M., M.J. Kruhlak, A.K. Box, M.J. Hendzel, and D.P. Bazett-Jones. 2001. The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body. J Cell Biol. 152:1099-106.

Fischle, W., F. Dequiedt, M. Fillion, M.J. Hendzel, W. Voelter, and E. Verdin. 2001. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem. 276:35826-35.

Kruhlak, M.J., M.J. Hendzel, W. Fischle, N.R. Bertos, S. Hameed, X.J. Yang, E. Verdin, and D.P. Bazett-Jones. 2001. Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin. J Biol Chem. 276:38307-19.

McManus, K.J., and M.J. Hendzel. 2001. CBP, a transcriptional coactivator and acetyltransferase. Biochem Cell Biol. 79:253-66.

Histone H1 (2000-2006)

Th'ng, J.P., R. Sung, M. Ye, and M.J. Hendzel. 2005. H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain. J Biol Chem. 280:27809-14.

Hendzel, M.J., M.A. Lever, E. Crawford, and J.P. Th'ng. 2004. The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. J Biol Chem. 279:20028-34.

Lever, M.A., J.P. Th'ng, X. Sun, and M.J. Hendzel. 2000. Rapid exchange of histone H1.1 on chromatin in living human cells. Nature. 408:873-6.

 

 

Nuclear Structure, Function, and Dynamics (2000-2006) 

McDonald, D., G. Carrero, C. Andrin, G. de Vries, and M.J. Hendzel. 2006. Nucleoplasmic beta-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations. J Cell Biol. 172:541-52.

Carrero, G., M.J. Hendzel, and G. de Vries. 2006. Modelling the compartmentalization of splicing factors. J Theor Biol. 239:298-312.

Andrin, C., and M.J. Hendzel. 2004. F-actin-dependent insolubility of chromatin-modifying components. J Biol Chem. 279:25017-23.

Carrero, G., E. Crawford, M.J. Hendzel, and G. de Vries. 2004a. Characterizing fluorescence recovery curves for nuclear proteins undergoing binding events. Bull Math Biol. 66:1515-45.

Carrero, G., E. Crawford, J. Th'ng, G. de Vries, and M.J. Hendzel. 2004b. Quantification of protein-protein and protein-DNA interactions in vivo, using fluorescence recovery after photobleaching. Methods Enzymol. 375:415-42.

Carrero, G., D. McDonald, E. Crawford, G. de Vries, and M.J. Hendzel. 2003. Using FRAP and mathematical modeling to determine the in vivo kinetics of nuclear proteins. Methods. 29:14-28.

Hendzel, M.J., M.J. Kruhlak, N.A. MacLean, F. Boisvert, M.A. Lever, and D.P. Bazett-Jones. 2001. Compartmentalization of regulatory proteins in the cell nucleus. J Steroid Biochem Mol Biol. 76:9-21.

Kruhlak, M.J., M.A. Lever, W. Fischle, E. Verdin, D.P. Bazett-Jones, and M.J. Hendzel. 2000. Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments. J Cell Biol. 150:41-51.

Maxwell, C.A., and M.J. Hendzel. 2001. The integration of tissue structure and nuclear function. Biochem Cell Biol. 79:267-74.

Boisvert, F.M., M.J. Kruhlak, A.K. Box, M.J. Hendzel, and D.P. Bazett-Jones. 2001. The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body. J Cell Biol. 152:1099-106.

Boisvert, F.M., M.J. Hendzel, and D.P. Bazett-Jones. 2000. Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA. J Cell Biol. 148:283-92.

DNA Damage and DNA Repair (2000-2006)

Boisvert, F.M., M.J. Hendzel, J.Y. Masson, and S. Richard. 2005. Methylation of MRE11 regulates its nuclear compartmentalization. Cell Cycle. 4:981-9.

Gagne, J.P., M.E. Bonicalzi, P. Gagne, M.E. Ouellet, M.J. Hendzel, and G.G. Poirier. 2005. Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles. Biochem J. 392:499-509.

Gagne, J.P., M.J. Hendzel, A. Droit, and G.G. Poirier. 2006. The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives. Curr Opin Cell Biol. 18:145-51.

Haince, J.F., M.E. Ouellet, D. McDonald, M.J. Hendzel, and G.G. Poirier. 2006. Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage. Biochim Biophys Acta. 1763:226-37.

Haince, J.F., M. Rouleau, M.J. Hendzel, J.Y. Masson, and G.G. Poirier. 2005. Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy. Trends Mol Med. 11:456-63.

Han, J., M.J. Hendzel, and J. Allalunis-Turner. 2006. Quantitative analysis reveals asynchronous and more than DSB-associated histone H2AX phosphorylation after exposure to ionizing radiation. Radiat Res. 165:283-92.

Rodrigue, A., M. Lafrance, M.C. Gauthier, D. McDonald, M. Hendzel, S.C. West, M. Jasin, and J.Y. Masson. 2006. Interplay between human DNA repair proteins at a unique double-strand break in vivo. Embo J. 25:222-31.